Changes of cell volume and nitric oxide concentration in macula densa cells caused by changes in luminal NaCl concentration.

@article{Liu2002ChangesOC,
  title={Changes of cell volume and nitric oxide concentration in macula densa cells caused by changes in luminal NaCl concentration.},
  author={Ruisheng Liu and J{\'a}nos Pittner and Anders Erik Gosta Persson},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2002},
  volume={13 11},
  pages={2688-96}
}
The luminal NaCl concentration ([NaCl]) at the macula densa (MD) controls both tubuloglomerular feedback (TGF) and renin release. Nitric oxide (NO) inhibits TGF sensitivity to a great extent. The NO concentration in the MD cells is not known. This study measured this concentration in MD cells with confocal microscopy in the isolated perfused thick ascending limb using a NO-sensitive fluorophore 4,5-diaminofluorescein (DAF-2). Calcein was used to measure cell volume changes. The loop perfusion… CONTINUE READING
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