Changes of biological properties and pathogenesis of CAEV chimeras expressing Nef and Vpx/Vpr accessory proteins in infected goats

@article{Jin2009ChangesOB,
  title={Changes of biological properties and pathogenesis of CAEV chimeras expressing Nef and Vpx/Vpr accessory proteins in infected goats},
  author={Yuhai Jin and G{\'e}raldine Arrode-Brus{\'e}s and Naomi Halloway and Opendra Narayan and Yahia Chebloune},
  journal={Retrovirology},
  year={2009},
  volume={6},
  pages={P22 - P22}
}
Background Caprine Arthritis Encephalitis Virus (CAEV) is a goat lentivirus closely related to HIV that is naturally attenuated with only a minor proportion of infected goats that develop inflammatory diseases, in absence of progression in AIDS. In contrast, to HIV CAEV does not infect productively the CD4+ T cells and has a simpler genome organization. Indeed, CAEV lacks 3 out of 6 regulatory/accessory genes found in HIV. We thought that CAEV/goat is an excellent model to study the functions… CONTINUE READING
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