Changes of GABA receptors and dopamine turnover in the postmortem brains of parkinsonians with levodopa-induced motor complications.

@article{Calon2003ChangesOG,
  title={Changes of GABA receptors and dopamine turnover in the postmortem brains of parkinsonians with levodopa-induced motor complications.},
  author={Fr{\'e}d{\'e}ric Calon and Marc P. Morissette and Ali H. Rajput and Oleh Hornykiewicz and Paul J. B{\'e}dard and Th{\'e}r{\`e}se Di Paolo},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={2003},
  volume={18 3},
  pages={241-53}
}
Brain samples from 14 Parkinson's disease patients, 10 of whom developed motor complications (dyskinesias and/or wearing-off) on dopaminomimetic therapy, and 11 controls were analyzed. Striatal 3beta-(4-(125)I-iodophenyl)tropane-2beta-carboxylic acid isopropyl ester ([(125)I]RTI-121) -specific binding to dopamine transporter and concentration of dopamine were markedly decreased, but no association between level of denervation and development of motor complications was observed. The homovanillic… CONTINUE READING
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