Changes of DNA methylation level and spatial arrangement of primordial germ cells in embryonic day 15 to embryonic day 28 pig embryos.

@article{Hyldig2011ChangesOD,
  title={Changes of DNA methylation level and spatial arrangement of primordial germ cells in embryonic day 15 to embryonic day 28 pig embryos.},
  author={Sara Maj Watjen Hyldig and Olga Ostrup and Morten Vejlsted and Preben Dybdahl Thomsen},
  journal={Biology of reproduction},
  year={2011},
  volume={84 6},
  pages={1087-93}
}
The mammalian germline is generally assumed to undergo extensive epigenetic reprogramming during embryonic development, including a nearly complete erasure of DNA methylation. This assumption does, however, to large degree rely on data from mouse, and despite a well-grounded picture the general nature of these data needs to be validated by investigations of other mammalian species. This study represents such a contribution in the examination of the germline in the domestic pig (Sus scrofa… CONTINUE READING

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