Changes in uterine innervation in pregnancy and during labour

@article{Tingker2010ChangesIU,
  title={Changes in uterine innervation in pregnancy and during labour},
  author={Berith K Ting{\aa}ker and Lars Irestedt},
  journal={Current Opinion in Anaesthesiology},
  year={2010},
  volume={23},
  pages={300–303}
}
Purpose of review The present review highlights recent findings focusing on effects on the cervical innervation exerted by term pregnancy and labour. Recent findings The corpus uteri is almost denervated in term pregnancy, as demonstrated in both humans and rodents, whereas the cervical innervation remains dense throughout pregnancy and labour. In rats, fewer connections between sensory subdivisions in spinal cord segments and the cervix have been observed in late pregnancy as compared with the… Expand
Increased Nerve Fibers in Placental Bed Myometrium in Women With Preeclampsia
TLDR
Narrowing of the uterine spiral arterioles below the deciduomyometrial junction is 1 of the key pathophysiological changes in women with preeclampsia and increased nerve fibers in the placental bed myometrium may play a role in the pathogenesis of the preeclamping. Expand
Effect of chronic pretreatment with 17β-estradiol and/or progesterone on the nociceptive response to uterine cervical distension in a rat model.
TLDR
Estrogen is involved in uterine cervical nociception, while progesterone plays less of a significant role, and ovariectomy inhibited the increase in c-fos expression induced by visceral pain. Expand
A novel visceral pain model of uterine cervix inflammation in rat.
TLDR
Injection of capsaicin into the uterine cervix in rats could be a practical model of inflammatory cervical pain, which can be evaluated using the novel pain score derived from particular behaviors, based on Pearson's correlation analysis and regression analysis. Expand
Role of Nerve Fibres in Endometriosis
TLDR
Increased numbers of nerve fibres, increased amount of neurotrophins and different types of nerve Fibres in endometriosis may explain why women with endometRIosis experience pain. Expand
Non-Invasive Ring Electrode With a Wireless Electrical Recording and Stimulating System for Monitoring Preterm Labor
  • Yijae Lee, Changhyuk Lee, +5 authors Soo Hyun Lee
  • Medicine
  • IEEE Transactions on Neural Systems and Rehabilitation Engineering
  • 2020
TLDR
It is confirmed that the uterine contraction force in mice can be decreased by the application of electrical stimulation and it seemed that the continuous and various electrical stimulations affected the delay or inhibition of childbirth in the pregnant minipig. Expand
“Luteal Analgesia”: Progesterone Dissociates Pain Intensity and Unpleasantness by Influencing Emotion Regulation Networks
TLDR
It is demonstrated that physiologically high progesterone levels are associated with a reduction in the affective component of the pain experience and a dissociation between pain intensity and unpleasantness. Expand
Human labour pain is influenced by the voltage-gated potassium channel KV6.4 subunit
TLDR
KV6.4 can influence human labour pain by modulating the excitability of uterine nociceptor genes Trpv1 and Scn10a and has a higher action potential threshold. Expand
Paracervical block as pain treatment during second-trimester medical termination of pregnancy: an RCT with bupivacaine versus sodium chloride.
TLDR
There were no clinically significant differences between groups receiving PCB with bupivacaine or saline with regard to the highest and lowest pain intensity, morphine consumption or induction-to abortion interval. Expand
Pain Relief Effect of Cryotherapy in Parturients
TLDR
Cryotherapy proved effective in relieving pain in childbirth because characteristically, cryotherapy does not interfere in the physiological process of childbirth, it can be used in care for women in labor. Expand
Vulvodynia
TLDR
This Primer by Bergeron and colleagues summarizes the epidemiology, mechanisms, diagnosis and treatment of vulvodynia, a condition that is characterized by pain in the vulva. Expand
...
1
2
...

References

SHOWING 1-10 OF 64 REFERENCES
Immunohistochemical evidence for preserved innervation of the human cervix during pregnancy.
TLDR
It is suggested that the segmental difference in innervation of the human uterus (corpus versus cervix) may have specific importance for myometrial and cervical contractility during pregnancy and parturition. Expand
Influence of pregnancy and labor on the occurrence of nerve fibers expressing the capsaicin receptor TRPV1 in human corpus and cervix uteri
TLDR
The data suggest that TRPV1 may be involved in pain mechanisms associated with cervical ripening and labor, and support the concept that cervix uteri may be the major site from which labor pain emanates. Expand
Unaltered innervation of the human cervix uteri in contrast to the corpus during pregnancy and labor as revealed by PGP 9.5 immunohistochemistry.
TLDR
The innervation of the cervix uteri is dense and unaltered throughout pregnancy and labor, in contrast, the corpus is almost denervated. Expand
Pregnancy Increases Excitability of Mechanosensitive Afferents Innervating the Uterine Cervix
TLDR
Data suggest that, close to the onset of labor, there is an increased input to the spinal cord from cervical distension and an increased depolarization of afferent terminals in the cervix, effects that could influence pain and the progress of labor. Expand
Retrograde tracing of spinal cord connections to the cervix with pregnancy in mice.
TLDR
The findings suggest that the predominant innervation of the murine cervix is from the sensory regions of the thoracolumbar spinal cord, and that these connections diminish with pregnancy, raising the possibility that the remaining connections from sensory and autonomic subdivisions, particularly the intermediolateral column, of the spinal cord may be important for increased density of nerve fibers in the cervix as pregnancy nears term. Expand
Sensory nerves and neuropeptides in uterine cervical ripening
TLDR
New data about the nervous system of the rat uterine cervix is revealed and it is revealed that these nerves and their transmitters could very well be part of a neurogenic inflammatory process involved in cervical ripening. Expand
Cervix remodeling and parturition in the rat: lack of a role for hypogastric innervation.
TLDR
The contention that enhanced innervation and immigration of immune cells are associated with remodeling of the cervix and parturition is supported, but that a neural pathway other than the hypogastric nerve may participate in the process of cervical ripening is questioned. Expand
Structural and Functional Evidence for the Denervation of Human Myometrium During Pregnancy
TLDR
It is concluded that the described decrease of nerve fibers within the myometrium of the pregnant uterus may be of importance for theMyometrial activity during pregnancy and parturition. Expand
Increased Innervation and Ripening of the Prepartum Murine Cervix
TLDR
The findings suggest that increased bNOS and CGRP innervation contribute to early inflammatory-like processes that ripen the cervix before birth. Expand
Leukocyte density and pro-inflammatory cytokine expression in human fetal membranes, decidua, cervix and myometrium before and during labour at term.
TLDR
Histological analysis demonstrated that leukocytes (predominantly neutrophils and macrophages) infiltrate the uterine cervix coincident with the onset of labour, lending further support to the hypothesis that labour is an inflammatory process. Expand
...
1
2
3
4
5
...