Changes in type II cell populations in monocrotaline pneumotoxicity.

  title={Changes in type II cell populations in monocrotaline pneumotoxicity.},
  author={Dennis W. Wilson and Henry J Segall},
  journal={The American journal of pathology},
  volume={136 6},
Unlike many other systemically administered pneumotoxicants affecting alveolar septa, Monocrotaline (MCT) does not cause a proliferative type II cell response. To determine whether MCT has an effect that might alter the type II cell response, we determined the numerical density and volume of type II cells in lungs from MCT-treated rats. Morphometric parameters were derived from estimates of nuclear volume based on point and intercept ratios counted in electron micrographs of type II cell… CONTINUE READING