Changes in tumor growth and metastatic capacities of J82 human bladder cancer cells suppressed by down-regulation of calreticulin expression.

@article{Lu2011ChangesIT,
  title={Changes in tumor growth and metastatic capacities of J82 human bladder cancer cells suppressed by down-regulation of calreticulin expression.},
  author={Yi-Chien Lu and Chiung-Nien Chen and Bojeng Wang and W M Hsu and Szu-Ta Chen and King-Jen Chang and Cheng-Chi Chang and Hsinyu Lee},
  journal={The American journal of pathology},
  year={2011},
  volume={179 3},
  pages={1425-33}
}
Bladder cancer is a common urothelial cancer. Through proteomic approaches, calreticulin (CRT) was identified and proposed as a urinary marker for bladder cancer. CRT is a multifunctional molecular chaperone that regulates various cellular functions such as Ca(2+) homeostasis and cell adhesion. CRT is overexpressed in various cancers, but its mechanism of action in the development of bladder tumors remains unclear. We generated J82 bladder cancer cells lines that either stably overexpressed or… CONTINUE READING

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