Changes in the total number of dentate granule cells in juvenile and adult rats: A correlated volumetric and 3H-thymidine autoradiographic study

@article{Bayer2004ChangesIT,
  title={Changes in the total number of dentate granule cells in juvenile and adult rats: A correlated volumetric and 3H-thymidine autoradiographic study},
  author={Shirley A. Bayer},
  journal={Experimental Brain Research},
  year={2004},
  volume={46},
  pages={315-323}
}
  • S. Bayer
  • Published 2004
  • Biology
  • Experimental Brain Research
SummaryThe total number of granule cells in the dentate gyrus was estimated in 17 male rats, four each aged 30, 120, and 200 days, and five aged 365 days. There is a substantial 35–43% linear increase between 1 month and 1 year. Two parameters of the granular layer are involved in the numerical change. First, total granular layer volume grows linearly with age. Second, average volume of a single granule cell nucleus in the ventral dentate gyrus decreases with age. Older rats tend to have a… 

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References

SHOWING 1-10 OF 38 REFERENCES

Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats

It is postulated that undifferentiated cells migrate postnatally from the forebrain ventricles to the hippocampus where they become differentiated, implicating that they may function as receptors of gonadal hormones.

An autoradiographic study of the time of origin and the pattern of granule cell migration in the dentate gyrus of the rat

The dentate gyrus of the rat contains about 600,000 granule cells. These small neurons are generated over a prolonged period from the 14th day of gestation until sime time after the second postnatal

Development of the hippocampal region in the rat I. Neurogenesis examined with 3H‐thymidine autoradiography

  • S. Bayer
  • Biology
    The Journal of comparative neurology
  • 1980
Neurogenesis in the rat hippocampal region was examined with 3H‐thymidine autoradiography and the percentage of labelled cells and the proportion of cells added during each day of formation were determined at several anatomical levels.

The postnatal development of the main olfactory bulb of the rat.

The postnatal development from birth to 1 year of the main olfactory bulb was examined quantitatively and some primitive cells could still be found at one year of age and there was an increase in the total number of granule cells beyond day 30.

Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb

  • J. Altman
  • Biology
    The Journal of comparative neurology
  • 1969
The results established that the major target structure of cell production in the subependymal layer of the lateral ventricle in young‐adult rats is the olfactory bulb, with only moderate contribution made to the anterior neocortex and basal ganglia.

Autoradiographic and histological studies of post-natal neurogenesis IV

The results established that the major target structure of cell production in the subependymal layer of the lateral ventricle in young-adult rats is the olfactory bulb, with only moderate contribution made to the anterior neocortex and basal ganglia.

Autoradiographic and histological studies of postnatal neurogenesis. I. A longitudinal investigation of the kinetics, migration and transformation of cells incoorporating tritiated thymidine in neonate rats, with special reference to postnatal neurogenesis in some brain regions

It was established that cells multiplying in the ependymal and subependymal walls of the Olfactory ventricle migrate outward into the olfactory bulb, where they become differentiated into granule cells, and, to a lesser extent, other types of nerve cells of the cerebellar cortex.

Autoradiographic investigation of cell proliferation in the brains of rats and cats

The results indicate that glia cells can multiply in the brains of young adult rats and adult cats and they support the possibility that new neurons may be formed in forebrain structures, both in rodents and carnivores.

Behavioural effects of interference with the postnatal acquisition of hippocampal granule cells.

Irradiation of the infant rat hippocampus using a schedule derived from previous cerebellar autoradiographic and irradiation studies should reduce the population of granule cells without directly harming the prenatally-formed pyramidal cells of Amnion's horn.

Autoradiographic and histological studies of postnatal neurogenesis. III. Dating the time of production and onset of differentiation of cerebellar microneurons in rats

  • J. Altman
  • Biology
    The Journal of comparative neurology
  • 1969
In one experiment rats were injected with single does of thymidine‐H3 at 6 hours, 2, 6 and 13 days of age, or with multiple doses during two periods of early life, and were killed when 2, 4 and 6