Changes in the sympathetic innervation of the gut in rotenone treated mice as possible early biomarker for Parkinson’s disease

@inproceedings{Arnhold2016ChangesIT,
  title={Changes in the sympathetic innervation of the gut in rotenone treated mice as possible early biomarker for Parkinson’s disease},
  author={Mike Arnhold and Yanina Dening and Micha{\"e}l Chopin and Esteban Ar{\'e}valo and Mathias Schwarz and Heinz Reichmann and Gabriele Gille and Richard W. H. Funk and Francisco Pan-Montojo},
  booktitle={Clinical Autonomic Research},
  year={2016}
}
Involvement of the peripheral nervous system (PNS) is relatively common in Parkinson’s disease (PD) patients. PNS alterations appear early in the course of the disease and are responsible for some of the non-motor symptoms observed in PD patients. In previous studies, we have shown that environmental toxins can trigger the disease by acting on the enteric nervous system. Here, we analyzed the effect of mitochondrial Complex I inhibition on sympathetic neuritis in vivo and sympathetic neurons in… CONTINUE READING

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