Changes in the subcellular distribution of metabolites due to ethanol oxidation in the perfused rat liver.

@article{Soboll1981ChangesIT,
  title={Changes in the subcellular distribution of metabolites due to ethanol oxidation in the perfused rat liver.},
  author={Sibylle Soboll and Hans Walter Heldt and Roland W. Scholz},
  journal={Hoppe-Seyler's Zeitschrift fur physiologische Chemie},
  year={1981},
  volume={362 3},
  pages={
          247-60
        }
}
The subcellular distribution of metabolites involved in the transfer of reducing equivalents across the mitochondrial membrane was studied in perfused livers from fed rats. A tenfold increase in the flux rate of the malate-aspartate shuttle and the inhibition of the citrate cycle due to ethanol oxidation, were reflected by characteristic changes in the cytosolic and mitochondrial concentrations of malate, 2-oxoglutarate, aspartate, glutamate and citrate. The data suggest that the malate… CONTINUE READING
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