Changes in the structure-function relationship of elastin and its impact on the proximal pulmonary arterial mechanics of hypertensive calves.

  title={Changes in the structure-function relationship of elastin and its impact on the proximal pulmonary arterial mechanics of hypertensive calves.},
  author={Steven R. Lammers and Philip H. Kao and Hang Jerry Qi and Kendall Stephen Hunter and Craig J. Lanning and Joseph A. Albietz and Stephen Hofmeister and Robert P. Mecham and Kurt R. Stenmark and Robin Shandas},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={295 4},
  • S. LammersP. Kao R. Shandas
  • Published 1 October 2008
  • Engineering, Biology
  • American journal of physiology. Heart and circulatory physiology
Extracellular matrix remodeling has been proposed as one mechanism by which proximal pulmonary arteries stiffen during pulmonary arterial hypertension (PAH). Although some attention has been paid to the role of collagen and metallomatrix proteins in affecting vascular stiffness, much less work has been performed on changes in elastin structure-function relationships in PAH. Such work is warranted, given the importance of elastin as the structural protein primarily responsible for the passive… 

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