Changes in the structure-function relationship of elastin and its impact on the proximal pulmonary arterial mechanics of hypertensive calves.

@article{Lammers2008ChangesIT,
  title={Changes in the structure-function relationship of elastin and its impact on the proximal pulmonary arterial mechanics of hypertensive calves.},
  author={S. Lammers and P. Kao and H. Qi and K. Hunter and C. Lanning and Joseph A. Albietz and Stephen Hofmeister and R. Mecham and K. Stenmark and R. Shandas},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2008},
  volume={295 4},
  pages={
          H1451-9
        }
}
  • S. Lammers, P. Kao, +7 authors R. Shandas
  • Published 2008
  • Materials Science, Medicine
  • American journal of physiology. Heart and circulatory physiology
Extracellular matrix remodeling has been proposed as one mechanism by which proximal pulmonary arteries stiffen during pulmonary arterial hypertension (PAH). Although some attention has been paid to the role of collagen and metallomatrix proteins in affecting vascular stiffness, much less work has been performed on changes in elastin structure-function relationships in PAH. Such work is warranted, given the importance of elastin as the structural protein primarily responsible for the passive… Expand
Linked opening angle and histological and mechanical aspects of the proximal pulmonary arteries of healthy and pulmonary hypertensive rats and calves.
Impact of chronic hypoxia on proximal pulmonary artery wave propagation and mechanical properties in rats
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