Changes in the serum proteome associated with the development of hepatocellular carcinoma in hepatitis C-related cirrhosis

@article{Ward2006ChangesIT,
  title={Changes in the serum proteome associated with the development of hepatocellular carcinoma in hepatitis C-related cirrhosis},
  author={Douglas G. Ward and Yao Iris Cheng and Gis{\`e}le N'kontchou and Tsering Thar and Nathalie Barget and Wenbin Wei and Lucinda Jane Billingham and Ashley W. Martin and Michel Beaugrand and P J Johnson},
  journal={British Journal of Cancer},
  year={2006},
  volume={94},
  pages={287 - 292}
}
Early diagnosis of hepatocellular carcinoma (HCC) is the key to the delivery of effective therapies. The conventional serological diagnostic test, estimation of serum alpha-fetoprotein (AFP) lacks both sensitivity and specificity as a screening tool and improved tests are needed to complement ultrasound scanning, the major modality for surveillance of groups at high risk of HCC. We have analysed the serum proteome of 182 patients with hepatitis C-induced liver cirrhosis (77 with HCC) by surface… CONTINUE READING
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