Changes in the proteome associated with the action of Bcr-Abl tyrosine kinase are not related to transcriptional regulation.

@article{Smith2002ChangesIT,
  title={Changes in the proteome associated with the action of Bcr-Abl tyrosine kinase are not related to transcriptional regulation.},
  author={Duncan L Smith and Caroline A Evans and Andrew Pierce and Simon J. Gaskell and Anthony D. Whetton},
  journal={Molecular & cellular proteomics : MCP},
  year={2002},
  volume={1 11},
  pages={
          876-84
        }
}
Chronic myeloid leukemia (CML) is a hematopoietic stem cell disease, the hallmark of which is the Bcr-Abl protein tyrosine kinase (PTK). Without intervention the disease progresses from a benign chronic phase to a rapidly fatal blast crisis. To identify the molecular mechanisms underlying disease progression we used two-dimensional gel electrophoresis on a model we have previously described using the expression of a conditional mutant of Bcr-Abl PTK in a multipotent stem cell line, FDCP-Mix… CONTINUE READING

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Bcr-Abl Effects on the Proteome 884 Molecular & Cellular Proteomics

  • M. J. Chalmers, S. J. Gaskell
  • Curr. Opin. Biotechnol
  • 2000

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