Changes in the primary outcome in Ebola vaccine trial--Authors' reply.

  title={Changes in the primary outcome in Ebola vaccine trial--Authors' reply.},
  author={Marie Paule Kieny and Ira M. Longini and Ana-Maria Henao-Restrepo and Conall H. Watson and Matthias Egger and W. John Edmunds},
  volume={387 10027},
} Vol 387 April 9, 2016 1509 Authors’ reply We thank Yanyu Zhang and colleagues for their interest in the methods of Ebola Ça suffit ring vaccination trial in Guinea and for their words of encouragement. In our article published in the British Medical Journal, we specifi ed that the primary analysis in a ring vaccination trial estimates vaccine effi cacy against Ebola virus disease. Vaccine efficacy is defined as VE=1−è, where è=ë1/ë0 is the hazard ratio of ë1 (the hazard of… CONTINUE READING
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