Changes in the patterns of collagens and fibronectin during limb-bud chondrogenesis.

  title={Changes in the patterns of collagens and fibronectin during limb-bud chondrogenesis.},
  author={Waltraud Dessau and Helga von der Mark and Klaus von der Mark and Silvia Fischer},
  journal={Journal of embryology and experimental morphology},
The distribution and sequence of appearance of fibronectin and of type-I and type-II collagen in the developing cartilage models of embryonic chick hind-limb buds was studied by immunofluorescence, using specific antibodies directed against these proteins. Fibronectin and type-I collagen are evenly distributed throughout the intercellular space of the mesenchyme prior to condensation of core mesenchyme of the limb anlage and formation of the cartilage blastema. With the onset of the… CONTINUE READING


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