Changes in the number of rosette-forming cells in the spleen of mice tolerant to sheep red cells

Abstract

As a r e su l t of the induction of to lerance by injection of a l a rge dose of sheep red ce l l s and cyclophosphamide, the num ber of r o s e t t e f o r m i n g cel ls (~FCs) in the mouse spleen fell sha rp ly but it r e c o v e r e d again a f t e r 14 days. Injection of cyclophosphamide alone had no effect on the re la t ive n u m b e r o f R F C s . Af te r a t es t injection of red cei ls the number of RFCs, l ike the num ber of p laquefo rming cei ls , inc reased only sl ightly in the to le ran t an ima l s . A m a r k e d immune r e sponse fo r both indices was obse rved in the control an imals (intact mice and mice rece iv ing cyclophosphamide alone). The nature of RFCs in an imals to le ran t to sheep red ce l l s is d iscussed .

DOI: 10.1007/BF00797416

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Cite this paper

@article{Novikova1974ChangesIT, title={Changes in the number of rosette-forming cells in the spleen of mice tolerant to sheep red cells}, author={Tamara K. Novikova and L. A. Pevnitskii and Lev N. Fontalin}, journal={Bulletin of Experimental Biology and Medicine}, year={1974}, volume={77}, pages={537-541} }