Changes in the neuronal activity in the pedunculopontine nucleus in chronic MPTP-treated primates: an in situ hybridization study of cytochrome oxidase subunit I, choline acetyl transferase and substance P mRNA expression

@article{GomezGallego2006ChangesIT,
  title={Changes in the neuronal activity in the pedunculopontine nucleus in chronic MPTP-treated primates: an in situ hybridization study of cytochrome oxidase subunit I, choline acetyl transferase and substance P mRNA expression},
  author={Maria Gomez-Gallego and Emiliano Fern{\'a}ndez-Villalba and Andr{\'e}s Fern{\'a}ndez-Barreiro and Mar{\'i}a Trinidad Herrero},
  journal={Journal of Neural Transmission},
  year={2006},
  volume={114},
  pages={319-326}
}
The pedunculopontine nucleus is a mesencephalic nucleus that has widespread and reciprocal connections with the basal ganglia. It has been implicated in the physiopathology of akinesia, rigidity, gait failure and sleep disorders associated with Parkinson’s disease. In this study, in situ hybridization was used to examine the changes in neuronal metabolic activity (measuring cytochrome oxidase subunit I) and in the level of acetylcholine and Substance P synthesis in the pedunculopontine nucleus… CONTINUE READING
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