Changes in the nature of P-glycoprotein gene transcripts during the development of multidrug resistance in CHO cells.

Abstract

We have studied the nature of P-glycoprotein gene transcripts in multidrug resistant Chinese hamster ovary cell lines selected in vincristine. Using a novel, 35S based, reverse transcription polymerase chain reaction assay, we have shown that there is a considerable increase in the level of pgp2 gene transcripts, with levels rising to a hundred fold those… (More)

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Cite this paper

@article{Vickers1995ChangesIT, title={Changes in the nature of P-glycoprotein gene transcripts during the development of multidrug resistance in CHO cells.}, author={Selwyn Vickers and J. Roger Warr}, journal={Cell biology international}, year={1995}, volume={19 1}, pages={35-41} }