Changes in the mouse estrus cycle in response to BRCA1 inactivation suggest a potential link between risk factors for familial and sporadic ovarian cancer.

@article{Hong2010ChangesIT,
  title={Changes in the mouse estrus cycle in response to BRCA1 inactivation suggest a potential link between risk factors for familial and sporadic ovarian cancer.},
  author={Hao Hong and Hai-Yun Yen and Amy Brockmeyer and Ying Liu and Rajas Chodankar and Malcolm C. Pike and Frank Z. Stanczyk and Robert M Maxson and Louis Dubeau},
  journal={Cancer research},
  year={2010},
  volume={70 1},
  pages={221-8}
}
Menstrual cycle activity is the most important risk factor for sporadic serous ovarian carcinoma, whereas a germ-line mutation in BRCA1 is the most important risk factor for the familial form. Given the rarity of BRCA1 mutations in sporadic ovarian cancers, we hypothesized that BRCA1 influences the menstrual cycle in a way that mimics the factors underlying sporadic ovarian cancer predisposition, making BRCA1 mutations redundant in such cancers. We compared the length of each phase of the… CONTINUE READING
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Increased ovarian cancer risk Cancer Res

  • CL Pearce, K Chung, MC Pike, AH. Wu
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