Changes in the metabolic footprint of placental explant-conditioned medium cultured in different oxygen tensions from placentas of small for gestational age and normal pregnancies.

@article{Horgan2010ChangesIT,
  title={Changes in the metabolic footprint of placental explant-conditioned medium cultured in different oxygen tensions from placentas of small for gestational age and normal pregnancies.},
  author={Richard P. Horgan and David I. Broadhurst and Warwick B. Dunn and Merrick Brown and Alexander E P Heazell and Douglas B. Kell and Philip N. Baker and Louise C. Kenny},
  journal={Placenta},
  year={2010},
  volume={31 10},
  pages={
          893-901
        }
}
Being born small for gestational age (SGA) confers significantly increased risks of perinatal morbidity and mortality. Accumulating evidence suggests that an SGA fetus results from a poorly perfused and abnormally developed placenta. Some of the placental features seen in SGA, such as abnormal cell turnover and impaired nutrient transport, can be reproduced by culture of placental explants in hypoxic conditions. Metabolic footprinting offers a hypothesis-generating strategy to investigate… CONTINUE READING
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The difference in the metabolic footprint of placental villous explants cultured in different oxygen tensions

  • R Horgan, M Brown, W Dunn, A Heazell, D Kell, L Kenny
  • BJOG
  • 2009
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