Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease.

  title={Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease.},
  author={Maura Heverin and Nenad Bogdanovi{\'c} and Dieter L{\"u}tjohann and Thomas Bayer and Irina Pikuleva and Lionel Br{\'e}tillon and Ulf Diczfalusy and Bengt Winblad and Ingemar Bj{\"o}rkhem},
  journal={Journal of lipid research},
  volume={45 1},
24S-hydroxycholesterol is a side-chain oxidized oxysterol formed in the brain that is continuously crossing the blood-brain barrier to reach the circulation. There may be an opposite flux of 27-hydroxycholesterol, which is formed to a lower extent in the brain than in most other organs. Here we measured cholesterol, lathosterol, 24S- and 27-hydroxycholesterol, and plant sterols in four different brain areas of deceased Alzheimer's disease (AD) patients and controls. 24S-hydroxycholesterol was… CONTINUE READING


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