Changes in the intracellular accumulation and distribution of metallothionein in rat liver and kidney during postnatal development.

@article{Panemangalore1983ChangesIT,
  title={Changes in the intracellular accumulation and distribution of metallothionein in rat liver and kidney during postnatal development.},
  author={Myna Panemangalore and Dibyajyoti Banerjee and Satomi Onosaka and M. George Cherian},
  journal={Developmental biology},
  year={1983},
  volume={97 1},
  pages={95-102}
}
Metallothionein (MT) bound to zinc and copper was detected in high concentration in fetal and newborn rat livers by a cadmium saturation method. The levels of both hepatic zinc and MT remained high for the first 14 days after birth and decreased to adult levels by 24 days of age. There was a direct linear relationship between hepatic metallothionein and zinc concentrations during the first 31 days after birth. The ratio of MT to zinc levels also decreased with age suggesting a rapid degradation… CONTINUE READING

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