Changes in the host natural killer cell population in mice during tumor development. 2. The mechanism of suppression of NK activity.

@article{Parhar1985ChangesIT,
  title={Changes in the host natural killer cell population in mice during tumor development. 2. The mechanism of suppression of NK activity.},
  author={Ranjit S. Parhar and P. K. Lala},
  journal={Cellular immunology},
  year={1985},
  volume={93 2},
  pages={265-79}
}
Our earlier studies revealed that a rapid and progressive loss of splenic NK activity in mice during the development of a number of transplanted tumors as well as of spontaneous tumors was due to an inactivation of natural killer (NK) lineage cells rather than to their disappearance. The mechanism of this inactivation have now been explored in CBA/J mice receiving transplanted Ehrlich ascites tumors and in C3H/HeJ mice bearing spontaneous mammary tumors or receiving transplants of syngeneic… CONTINUE READING
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