Changes in the expression of telomere maintenance genes suggest global telomere dysfunction in B-chronic lymphocytic leukemia.

@article{Poncet2008ChangesIT,
  title={Changes in the expression of telomere maintenance genes suggest global telomere dysfunction in B-chronic lymphocytic leukemia.},
  author={Delphine A Poncet and Aur{\'e}lie Belleville and Claire t'kint de Roodenbeke and Aude Roborel de Climens and Elsa Ben Simon and H{\'e}l{\`e}ne Merle-B{\'e}ral and Evelyne Callet‐Bauchu and Gilles Andr{\'e} Salles and Laure Sabatier and Jozo Delic and Eric Gilson},
  journal={Blood},
  year={2008},
  volume={111 4},
  pages={
          2388-91
        }
}
In this study, we explored the telomeric changes that occur in B-chronic lymphocytic leukemia (B-CLL), in which telomere length has recently been demonstrated to be a powerful prognostic marker. We carried out a transcriptomic analysis of telomerase components (hTERT and DYSKERIN), shelterin proteins (TRF1, TRF2, hRAP1, TIN2, POT1, and TPP1), and a set of multifunctional proteins involved in telomere maintenance (hEST1A, MRE11, RAD50, Ku80, and RPA1) in peripheral B cells from 42 B-CLL patients… 
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Telomere status in chronic lymphocytic leukemia with TP53 disruption
TLDR
It is demonstrated that patients with disrupted TP53 have severe telomere dysfunction and high genomic instability, and the telomeric profile could be tested as a biomarker in CLL patients treated with new therapeutic agents.
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The study suggests that impairment of telomere/telomerase system represents an early event in CLL pathogenesis and supports the involvement of DNA hypomethylation to increase chromosome instability.
Differential Expression of Non-Shelterin Genes Associated with High Telomerase Levels and Telomere Shortening in Plasma Cell Disorders
TLDR
The expression profile of a set of non-shelterin genes involved in essential processes such as replication, DNA damage repair pathways and stabilization of telomerase complex is investigated in patients with monoclonal gammopathy of undetermined significance and 40 cases with multiple myeloma.
Telomeric damage in early stage of chronic lymphocytic leukemia correlates with shelterin dysregulation.
TLDR
It is proposed that telomeric deprotection in the early step of CLL is not merely the consequence of telomere shortening but also of shelterin alteration.
Telomere Dysfunction in Chronic Lymphocytic Leukemia
TLDR
A more dynamic role of telomere dysfunction in shaping the disease course is suggested and processes leading to shelterin deregulation as well as cell intrinsic and microenvironmental factors underlying TERT activation are poorly understood.
Aberrant levels of SUV39H1 and SUV39H2 methyltransferase are associated with genomic instability in chronic lymphocytic leukemia
TLDR
The data show that the differential expression of SUV39H1 and SUV39h2 is associated with genomic instability and that the modulation of these HMTases can be an attractive approach to prevent CLL evolution.
Telomeres and prognosis in patients with chronic lymphocytic leukaemia
TLDR
The telomere length, telomerase activity, the mutation load of immunoglobulin variable heavy chain (IGHV) genes, and established prognostic factors were investigated and the ΔTL was found to be a reliable prognostic marker for patients with CLL.
A novel spliced variant of the TIN2 shelterin is present in chronic lymphocytic leukemia.
correlates with shelterin dysregulation Telomeric damage in early stage of chronic lymphocytic leukemia
TLDR
In a series restricted to 23 newly diagnosed Binet stage A CLL patients compared to 12 healthy donors, a significant increase in recruitment of DNA damage factors to telomeres showing telomere dysfunction in early stage of the disease is found.
Dysregulation of H/ACA ribonucleoprotein components in chronic lymphocytic leukemia
TLDR
A role for H/ACA RNP complex genes in genomic instability and telomere dysfunction in CLL is suggested and a link between gene expression and clinical parameters was found.
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