Changes in the expression of telomere maintenance genes suggest global telomere dysfunction in B-chronic lymphocytic leukemia.

@article{Poncet2008ChangesIT,
  title={Changes in the expression of telomere maintenance genes suggest global telomere dysfunction in B-chronic lymphocytic leukemia.},
  author={Delphine A Poncet and Aur{\'e}lie Belleville and Claire t'kint de Roodenbeke and Aude Roborel de Climens and Elsa Ben Simon and H{\'e}l{\`e}ne Merle-B{\'e}ral and Evelyne Callet‐Bauchu and Gilles Andr{\'e} Salles and Laure Sabatier and Jozo Delic and Eric Gilson},
  journal={Blood},
  year={2008},
  volume={111 4},
  pages={
          2388-91
        }
}
In this study, we explored the telomeric changes that occur in B-chronic lymphocytic leukemia (B-CLL), in which telomere length has recently been demonstrated to be a powerful prognostic marker. We carried out a transcriptomic analysis of telomerase components (hTERT and DYSKERIN), shelterin proteins (TRF1, TRF2, hRAP1, TIN2, POT1, and TPP1), and a set of multifunctional proteins involved in telomere maintenance (hEST1A, MRE11, RAD50, Ku80, and RPA1) in peripheral B cells from 42 B-CLL patients… 

Tables from this paper

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correlates with shelterin dysregulation Telomeric damage in early stage of chronic lymphocytic leukemia
TLDR
In a series restricted to 23 newly diagnosed Binet stage A CLL patients compared to 12 healthy donors, a significant increase in recruitment of DNA damage factors to telomeres showing telomere dysfunction in early stage of the disease is found.
Dysregulation of H/ACA ribonucleoprotein components in chronic lymphocytic leukemia
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