Changes in the expression of telomere maintenance genes suggest global telomere dysfunction in B-chronic lymphocytic leukemia.

@article{Poncet2008ChangesIT,
  title={Changes in the expression of telomere maintenance genes suggest global telomere dysfunction in B-chronic lymphocytic leukemia.},
  author={Delphine A Poncet and Aur{\'e}lie Belleville and Claire t'kint de Roodenbeke and Aude Roborel de Climens and Elsa Ben Simon and H{\'e}l{\`e}ne Merle-B{\'e}ral and Evelyne Callet‐Bauchu and Gilles Andr{\'e} Salles and Laure Sabatier and Jozo Delic and Eric Gilson},
  journal={Blood},
  year={2008},
  volume={111 4},
  pages={
          2388-91
        }
}
In this study, we explored the telomeric changes that occur in B-chronic lymphocytic leukemia (B-CLL), in which telomere length has recently been demonstrated to be a powerful prognostic marker. We carried out a transcriptomic analysis of telomerase components (hTERT and DYSKERIN), shelterin proteins (TRF1, TRF2, hRAP1, TIN2, POT1, and TPP1), and a set of multifunctional proteins involved in telomere maintenance (hEST1A, MRE11, RAD50, Ku80, and RPA1) in peripheral B cells from 42 B-CLL patients… 
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It is demonstrated that patients with disrupted TP53 have severe telomere dysfunction and high genomic instability, and the telomeric profile could be tested as a biomarker in CLL patients treated with new therapeutic agents.
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TLDR
It is proposed that telomeric deprotection in the early step of CLL is not merely the consequence of telomere shortening but also of shelterin alteration.
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TLDR
A more dynamic role of telomere dysfunction in shaping the disease course is suggested and processes leading to shelterin deregulation as well as cell intrinsic and microenvironmental factors underlying TERT activation are poorly understood.
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TLDR
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TLDR
The telomere length, telomerase activity, the mutation load of immunoglobulin variable heavy chain (IGHV) genes, and established prognostic factors were investigated and the ΔTL was found to be a reliable prognostic marker for patients with CLL.
A novel spliced variant of the TIN2 shelterin is present in chronic lymphocytic leukemia.
correlates with shelterin dysregulation Telomeric damage in early stage of chronic lymphocytic leukemia
TLDR
In a series restricted to 23 newly diagnosed Binet stage A CLL patients compared to 12 healthy donors, a significant increase in recruitment of DNA damage factors to telomeres showing telomere dysfunction in early stage of the disease is found.
Dysregulation of H/ACA ribonucleoprotein components in chronic lymphocytic leukemia
TLDR
A role for H/ACA RNP complex genes in genomic instability and telomere dysfunction in CLL is suggested and a link between gene expression and clinical parameters was found.
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References

SHOWING 1-10 OF 24 REFERENCES
Increased expression of telomere length regulating factors TRF1, TRF2 and TIN2 in patients with adult T‐cell leukemia
TLDR
The results underscore the importance of telomerase and telomere length regulating factors as novel markers for ATL disease progression and as potential therapeutic targets for the treatment of HTLV‐I‐associated malignancies.
Expression of Telomere-Associated Genes as Prognostic Markers for Overall Survival in Patients with Non–Small Cell Lung Cancer
TLDR
RAP1 expression may be a useful biomarker of tumor progression and survival and the expression of RAP1 gene in tumors was highly predictive of overall survival.
Clinical significance of telomerase and its associate genes expression in the maintenance of telomere length in squamous cell carcinoma of the esophagus.
TLDR
Though telomerase expression is not related to tumor stages and prognosis, the data support that the TA increased as the TRFL decreased, probably under the control of hTERT, hTERC, and TRF1.
Telomere length identifies two different prognostic subgroups among VH-unmutated B-cell chronic lymphocytic leukemia patients
TLDR
TRF-L can be helpful to refine prognostication of B-CLL patients, particularly those with a VH-unmutated immunoglobulin sequence, and effectively predicts outcome in terms of TTFT, PFS and OS.
Telomere length and telomerase activity delineate distinctive replicative features of the B-CLL subgroups defined by immunoglobulin V gene mutations.
Patients with B-cell chronic lymphocytic leukemia (B-CLL) segregate into subgroups with very different survival times. Because clinical observations suggest that leukemic cells accumulate at…
Telomere length correlates with histopathogenesis according to the germinal center in mature B-cell lymphoproliferative disorders.
TLDR
The short TRF lengths of GC-inexperienced MBCLDs indicates that these neoplasms are good candidates for treatment with telomerase inhibitors, a class of molecules currently the subject of extensive preclinical evaluation.
Random aneuploidy and telomere capture in chronic lymphocytic leukemia and chronic myeloid leukemia patients.
Telomerase activity in normal leukocytes and in hematologic malignancies.
TLDR
The results suggest that early CLL and MDS cells lack an efficient mechanism of telomere maintenance and that telomerase is activated late in the progression of these cancers, presumably when critical telomerre loss generates selective pressure for cell immortality.
Expression of mRNAs for telomeric repeat binding factor (TRF)-1 and TRF2 in atypical adenomatous hyperplasia and adenocarcinoma of the lung.
  • K. Nakanishi, T. Kawai, E. Gilson
  • Biology, Medicine
    Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2003
TLDR
Investigating the expressions of the mRNAs encoded by the TERF1 and TERF2 genes using in situ hybridization in surgically resected specimens is consistent with (but not enough to confirm) the idea that high-grade AAH is closely related to BAC.
Gene Expression Profiling of B Cell Chronic Lymphocytic Leukemia Reveals a Homogeneous Phenotype Related to Memory B Cells 〉
TLDR
Comparison of CLL profiles with those of purified normal B cell subpopulations indicates that the common CLL profile is more related to memory B cells than to those derived from naive B cells, CD5+ B Cells, and GC centroblasts and centrocytes.
...
1
2
3
...