Changes in the expression of telomere maintenance genes suggest global telomere dysfunction in B-chronic lymphocytic leukemia.
@article{Poncet2008ChangesIT, title={Changes in the expression of telomere maintenance genes suggest global telomere dysfunction in B-chronic lymphocytic leukemia.}, author={Delphine A Poncet and Aur{\'e}lie Belleville and Claire t'kint de Roodenbeke and Aude Roborel de Climens and Elsa Ben Simon and H{\'e}l{\`e}ne Merle-B{\'e}ral and Evelyne Callet‐Bauchu and Gilles Andr{\'e} Salles and Laure Sabatier and Jozo Delic and Eric Gilson}, journal={Blood}, year={2008}, volume={111 4}, pages={ 2388-91 } }
In this study, we explored the telomeric changes that occur in B-chronic lymphocytic leukemia (B-CLL), in which telomere length has recently been demonstrated to be a powerful prognostic marker. We carried out a transcriptomic analysis of telomerase components (hTERT and DYSKERIN), shelterin proteins (TRF1, TRF2, hRAP1, TIN2, POT1, and TPP1), and a set of multifunctional proteins involved in telomere maintenance (hEST1A, MRE11, RAD50, Ku80, and RPA1) in peripheral B cells from 42 B-CLL patients…
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