Changes in the expression of many Ets family transcription factors and of potential target genes in normal mammary tissue and tumors.

@article{Galang2004ChangesIT,
  title={Changes in the expression of many Ets family transcription factors and of potential target genes in normal mammary tissue and tumors.},
  author={Christina K Galang and William J. Muller and Gabriele Foos and Robert G. Oshima and C. A. Hauser},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 12},
  pages={11281-92}
}
Interfering with Ets transcription factor function reverses multiple aspects of the transformed phenotype of mouse or human tumor cells. However, the unknown number of individual Ets factors expressed in any cellular context and the similar DNA binding specificities of Ets family members complicates the identification of those that mediate transformation. By utilizing quantitative PCR assays for 25 mouse Ets factors, we analyzed the expression of essentially the entire Ets family in normal… CONTINUE READING