Changes in the expression and localization of the paranodal protein Caspr on axons in chronic multiple sclerosis.

@article{Wolswijk2003ChangesIT,
  title={Changes in the expression and localization of the paranodal protein Caspr on axons in chronic multiple sclerosis.},
  author={Guus Wolswijk and Rawien A Balesar},
  journal={Brain : a journal of neurology},
  year={2003},
  volume={126 Pt 7},
  pages={1638-49}
}
The presence of intact paranodal junctions on myelinated axons in the CNS and PNS is crucial for both myelin sheath attachment and saltatory impulse conduction. The axonal glycoprotein contactin-associated protein (Caspr) is expressed in the paranodal region and plays an important role in the creation and maintenance of these adhesive junctions. In the present study, antibodies to Caspr were used to assess the integrity of paranodal junctions on myelinated axons in brain and spinal cord tissue… CONTINUE READING
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