Changes in the effect of spinal prostaglandin E2 during inflammation: prostaglandin E (EP1-EP4) receptors in spinal nociceptive processing of input from the normal or inflamed knee joint.

@article{Br2004ChangesIT,
  title={Changes in the effect of spinal prostaglandin E2 during inflammation: prostaglandin E (EP1-EP4) receptors in spinal nociceptive processing of input from the normal or inflamed knee joint.},
  author={Karl-J{\"u}rgen B{\"a}r and Gabriel Natura and Alejandro Telleria-Diaz and Philipp Teschner and Regine Vogel and Enrique Vasquez and H. -G. Schaible and Andrea Ebersberger},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2004},
  volume={24 3},
  pages={642-51}
}
Inflammatory pain is caused by sensitization of peripheral and central nociceptive neurons. Prostaglandins substantially contribute to neuronal sensitization at both sites. Prostaglandin E2 (PGE2) applied to the spinal cord causes neuronal hyperexcitability similar to peripheral inflammation. Because PGE2 can act through EP1-EP4 receptors, we addressed the role of these receptors in the spinal cord on the development of spinal hyperexcitability. Recordings were made from nociceptive dorsal horn… CONTINUE READING
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Novel four selective agonists for prostaglandin E receptor subtypes

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Novel four selective agonists for prostaglandin E receptor subtypes. Prostaglandins and other lipid mediators 59:150

  • H Yamamoto, T Maruyama, +7 authors S Ohuchida
  • 1999
Highly Influential
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