Changes in the distribution pattern of Claudin tight junction proteins during the progression of mouse skin tumorigenesis

Despite the fact that morphological and physiological observations suggest that the tight junction (TJ)-based permeability barrier is modified/disrupted in tumorigenesis, the role of members of the Claudin (Cldn) family of TJ proteins is not well-understood. Using a well-established two-stage chemical carcinogenesis model, we investigated the temporal and… CONTINUE READING