Changes in the dengue virus major envelope protein on passaging and their localization on the three-dimensional structure of the protein.

@article{Lee1997ChangesIT,
  title={Changes in the dengue virus major envelope protein on passaging and their localization on the three-dimensional structure of the protein.},
  author={Eva Y.-H.P Lee and Ronald C. Weir and Lynn Dalgarno},
  journal={Virology},
  year={1997},
  volume={232 2},
  pages={281-90}
}
To help define the molecular events involved in dengue virus adaptation during serial passage in vivo and in cultured cells, we have sequenced the structural protein genes of three dengue type 3 isolates after intracerebral passage in mice and after passage in cultured monkey kidney (Vero) and Aedes albopictus (mosquito) cells. Passaging in each host selected for amino acid changes in the envelope protein E and occasionally in prM but not in the capsid protein. Most changes were first apparent… CONTINUE READING
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