Changes in the cytoskeletal structure of human platelets following thrombin activation.

@article{Jennings1981ChangesIT,
  title={Changes in the cytoskeletal structure of human platelets following thrombin activation.},
  author={Lisa H K Jennings and Jennifer E. Fox and Helen H. Edwards and David R. Phillips},
  journal={The Journal of biological chemistry},
  year={1981},
  volume={256 13},
  pages={6927-32}
}
The temporal changes in human platelet actin polymerization, cytoskeletal morphology, and protein content that occur during thrombin-induced platelet activation were investigated by analysis of Triton-extracted platelets. Measurement of the DNase inhibitory activity of control platelets immediately after adding an equal volume of 2% Triton X-100, 10 mM ethylene glycol bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid, and 0.1 M Tris, pH 7.4, showed that approximately 50% of the actin in… CONTINUE READING

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