Changes in the concentrations of hepatic metabolites on administration of dihydroxyacetone or glycerol to starved rats and their relationship to the control of ketogenesis.

@article{Williamson1969ChangesIT,
  title={Changes in the concentrations of hepatic metabolites on administration of dihydroxyacetone or glycerol to starved rats and their relationship to the control of ketogenesis.},
  author={Dermot H. Williamson and Dorila Pil{\'o} Veloso and E V Ellington and Hans A. Krebs},
  journal={The Biochemical journal},
  year={1969},
  volume={114 3},
  pages={575-84}
}
1. Glycerol and dihydroxyacetone, both antiketogenic and readily metabolized, but differing in their effects on the redox state of the hepatic NAD couples, were given to starved rats and the contents of metabolites were measured in freezeclamped liver and in the blood. The object was to study the effects of changes in the redox state and of the availability of oxidizable substrates on the rate of ketone-body formation. 2. Intramuscular administration of dihydroxyacetone, glycerol or glucose to… CONTINUE READING