Changes in the binding capacity of alpha-1-acid glycoprotein in patients with renal insufficiency.

@article{Kishino1995ChangesIT,
  title={Changes in the binding capacity of alpha-1-acid glycoprotein in patients with renal insufficiency.},
  author={Satoshi Kishino and Akikazu Nomura and Zhongmin Di and Mitsuru Sugawara and Ken Iseki and Shigeo Kakinoki and Akira Kitabatake and Katsumi Miyazaki},
  journal={Therapeutic drug monitoring},
  year={1995},
  volume={17 5},
  pages={449-53}
}
The elevation of alpha-1-acid glycoprotein (AAG) concentration and the binding characteristics of disopyramide (DP) to AAG in patients with renal insufficiency were investigated. The serum AAG concentration and protein binding of DP in patients were significantly greater than those in healthy subjects. However, in both the serum and the purified AAG… CONTINUE READING