Changes in the baroreflex control of heart rate produced by central infusion of selective angiotensin antagonists in hypertensive rats.

@article{Oliveira1996ChangesIT,
  title={Changes in the baroreflex control of heart rate produced by central infusion of selective angiotensin antagonists in hypertensive rats.},
  author={Daniela Rodrigues de Oliveira and Robson Augusto Sousa dos Santos and George F Santos and Mahesh C Khosla and Maria Jos{\'e} Campagnole-Santos},
  journal={Hypertension},
  year={1996},
  volume={27 6},
  pages={1284-90}
}
We have recently shown that an angiotensin-(1-7) [Ang-(I-7)] analogue, D-Ala7-Ang-(1-7) (A-779), is a selective Ang-(1-7) antagonist with no significant action on angiotensin type 1 or type 2 receptors. The availability of selective angiotensin antagonists prompted us to evaluate the role of Ang-(1-7) and Ang II on central modulation of the baroreflex control of heart rate in normotensive Wistar rats and spontaneously hypertensive rats (SHR). Blood pressure recording and reflex changes in heart… CONTINUE READING

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