[Changes in the antibacterial activity of chemotherapeutic agents (especially carbapenems) for 10 species of clinical isolates between 1994 and 1996. Surveillance group of the sensitivities of clinical isolates to antibacterial agents].

Abstract

During October and December of each year of from 1994 to 1996, 3,849 strains of 10 species of bacteria were isolated from clinical materials in 21 institutions nationwide. The minimum inhibitory concentrations (MICs) for these bacteria of four carbapenems (imipenem [IPM], panipenem [PAPM], meropenem [MEPM], and biapenem [BIPM]) and other representative antibacterial agents were measured to investigate annual changes in antibacterial activity. Carbapenems showed potent activity against methicillin-sensitive S. aureus (MSSA), S. pneumoniae, E. faecalis, H. influenzae, E. coli, K. pneumoniae, E. cloacae, S. marcescens, and the B. fragilis group, with the activity being stable. However, these drugs showed weak activity against methicillin-resistant S. aureus (MRSA) and P. aeruginosa. The antibacterial activity (MIC90) against the tested organisms generally remained stable. Particularly, there was annual improvement of the MIC90 values of IPM and BIPM for S. pneumoniae, as well as the values of IPM and PAPM for H. influenzae, and those of IPM, PAPM, and BIPM for S. marcescens. On the other hand, the activity of carbapenems (including IPM) against MRSA was not necessarily strong, but there was annual improvement of MIC90 values.

Cite this paper

@article{Igari2000ChangesIT, title={[Changes in the antibacterial activity of chemotherapeutic agents (especially carbapenems) for 10 species of clinical isolates between 1994 and 1996. Surveillance group of the sensitivities of clinical isolates to antibacterial agents].}, author={Jun Igari and Naoto Watanabe and Nobuyuki Uehara and Masashi Inoue and Hideaki Yoshida and Yuji Imafuku and Takashi Nishino and Takazumi Shibano and Shuichi Satou and Ikuo Kobayashi and Akira Takahashi and Sachie Yomoda and Kentaro Matsuoka and Toyoko Oguri and Yuzo Ohba and Kazunari Kumasaka and Koichi Tokuda and Yutaka Kobayashi and Teruaki Hongo and Jun Okada and Toru Sasaki and Nozomu Matsumoto and Yasunobu Hirata and N Nakasaki and Junya Ono and Takashi Takata and Rumi Kawaguchi and Yoshimi Ohtaki and Katsunari Kajimura and Shiomi Ishigo and Takashi Hashimoto and Naoya Aoki and Eimei Okamoto and Eiki Murakami and Hiroshi Saeki}, journal={The Japanese journal of antibiotics}, year={2000}, volume={53 3}, pages={157-70} }