Changes in the aging immune system.

  title={Changes in the aging immune system.},
  author={Beatrix Grubeck-Loebenstein},
  journal={Biologicals : journal of the International Association of Biological Standardization},
  volume={25 2},
The functional capacity of the immune system gradually declines with age. T lymphocytes are more severely affected than B cells or antigen-presenting cells. This is mainly due to the involution of the thymus which is almost complete at the age of 60. The host is then dependent on the T cell pool generated in earlier life. Continuous activation, clonal expansion and elimination of T cells of various specificities eventually leads to changes in the T cell repertoire. CD45RA+ "naive" cells are… CONTINUE READING

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