Changes in the Wnt signalling pathway in gastrointestinal cancers and their prognostic significance.

@article{Doucas2005ChangesIT,
  title={Changes in the Wnt signalling pathway in gastrointestinal cancers and their prognostic significance.},
  author={Helena Doucas and Giuseppe S. Garcea and Christopher P. Neal and Margaret M. Manson and David Paul Berry},
  journal={European journal of cancer},
  year={2005},
  volume={41 3},
  pages={365-79}
}
Many steps in the Wnt signalling pathway may be altered during the process of carcinogenesis. This Review focuses on the changes observed in gastrointestinal cancers. A literature search was undertaken and the currently available data summarised. Understanding the alterations to this signalling pathway may help to reveal future targets for therapeutic agents. In addition, since in some tumours, levels of components of the Wnt pathway have been found to correlate with clinical stage, their… CONTINUE READING

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