Changes in the Responsiveness of the Hypothalamic-Pituitary-Gonadal Axis to Kisspeptin-10 Administration during Pubertal Transition in Boys

@inproceedings{Nabi2018ChangesIT,
  title={Changes in the Responsiveness of the Hypothalamic-Pituitary-Gonadal Axis to Kisspeptin-10 Administration during Pubertal Transition in Boys},
  author={Ghulam Nabi and Hamid Ullah and Suliman Khan and Fazal Wahab and Pengfei Duan and Rahim R. Ullah and Lunguang Yao and Muhammad Shahab},
  booktitle={International journal of endocrinology},
  year={2018}
}
In human, no studies are available regarding changes in kisspeptin1 receptor (KISS1R) sensitivity during pubertal transition. In this study, healthy boys were classified into 5 Tanner stages of puberty (n = 5/stage). Human kisspeptin-10 was administered to boys at each Tanner stage and to adult men (n = 5) as an IV bolus for comparison. Serial blood samples were collected for 30 min pre- and 120 min post-kisspeptin injection periods at 30 min interval for measuring plasma LH and testosterone… CONTINUE READING

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