Changes in the Count of Pancreatic b- and a-Cells and Blood Glucose Level in Rats with Alloxan-Induced Diabetes

Abstract

We estimated the count of pancreatic alpha- and beta-cells and blood glucose level at various stages of alloxan-induced diabetes in rats. Alloxan decreased the count of insulin-producing beta-cells, but increased the number of glucagon-secreting alpha-cells in the pancreas (week 1 of diabetes). These changes were accompanied by hyperglycemia. The decrease in blood glucose level in diabetic rats was associated with an increase in beta-cell count against the background of high density of pancreatic alpha-cells.

DOI: 10.1023/A:1015578201402

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Cite this paper

@article{Aleeva2002ChangesIT, title={Changes in the Count of Pancreatic b- and a-Cells and Blood Glucose Level in Rats with Alloxan-Induced Diabetes}, author={G. N. Aleeva and Andrey Pavlovich Kiyasov and M. M. Minnebaev and I. M. Burykin and R. Kh. Khafiz'yanova}, journal={Bulletin of Experimental Biology and Medicine}, year={2002}, volume={133}, pages={127-129} }