Changes in superoxide radical and lipid peroxide formation in the brain, heart and liver during the lifetime of the rat

@article{Sawada1987ChangesIS,
  title={Changes in superoxide radical and lipid peroxide formation in the brain, heart and liver during the lifetime of the rat},
  author={Masaaki Sawada and Jonathan C T Carlson},
  journal={Mechanisms of Ageing and Development},
  year={1987},
  volume={41},
  pages={125-137}
}
  • M. Sawada, J. Carlson
  • Published 1 November 1987
  • Medicine, Chemistry
  • Mechanisms of Ageing and Development
The free radical theory of aging was examined by measuring the formation of superoxide radical (SOR) and the level of lipid peroxides in various tissues of the aging rat. A significant increase in SOR production was seen in mitochondria prepared from the brain and the heart as rats aged. An elevation in the level of lipid peroxidation was also found in whole tissue homogenates of the brain and the liver. Vitamin E concentrations in the blood rose rapidly in young rats and remained steady except… 
Superoxide radical formation and associated biochemical alterations in the plasma membrane of brain, heart, and liver during the lifetime of the rat
TLDR
SOR formation appears to be enzyme‐mediated and elevated levels of this oxygen radical could be involved in membrane breakdown in older rats, and biochemical alterations in plasma membranes from brain, heart, and liver in aging rats are shown.
Lipid peroxidation and antioxidant enzymes in livers and brains of aged rats
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Although ascorbate-induced lipid peroxide levels remained unchanged in aged animals, hepatic lipid peroxidation was seen to be elevated and Glutathione (GSH) content was found to be decreased, but SOD and GPx remained unchanged.
Changes on cerebral antioxidant enzymes, peroxidation, and the glutathione system of frogs after aging and catalase inhibition
TLDR
The five major antioxidant enzymes, glutathione, and in vivo or in vitro stimulated (Fe++‐ascorbate) peroxidation were similar in old and young Rana perezi frogs, suggesting the possibiltity that O2‐free radicals be of minor importance in relation to brain aging in animals with low rates of oxygen consumption.
Expression of supreoxide dismutase and catalase in rat brain as a function of age
TLDR
The decrease in the activity of superoxide dismutase and catalase appears to be due to an age-dependent change in the expression of these genes.
Age-related changes of oxygen free radical production in the rat brain slice after hypoxia: on-line measurement using enhanced chemiluminescence
TLDR
A typical radical burst after reoxygenation is found which developed with aging and is almost nonexistent in the youngest and most prominent in the oldest group.
Age-related alterations in antioxidant capacity and lipid peroxidation in brain, liver, and lung homogenates of normal and vitamin E-deficient rats
TLDR
The overall antioxidant capacity of rat tissues appears to be maintained without large variation during ageing, and decreases in the capacity of some antioxidant factors may be compensated by increases in thecapacity of other factors.
Superoxide dismutase, glutathione peroxidase, catalase, and lipid peroxidation in the major organs of the aging rats.
TLDR
The results suggest that there is not any correlation between the SOD, CAT, and GSH-Px activities and the peroxidative status of the organs; thus, the age-related increase in the MDA content proposed as a criterion of aging process should be considered with caution.
Increased hepatic lipid peroxidation in aged mice
TLDR
Significant increases in both diene conjugate and malondialdehyde levels of liver homogenates and mitochondria and microsomes indicate that lipid peroxidation is important in advancing age in mice.
Glutathione metabolism in heart and liver of the aging rat.
TLDR
A decreased antioxidant capability has been demonstrated in both heart and liver of old rats with respect to the young animals and remained quite constant in 14- and 27-month-old rats.
Aging and lung antioxidant enzymes, glutathione, and lipid peroxidation in the rat.
TLDR
The results suggest that lung aging is not accelerated in old age due to a decrease in the antioxidant capacity of the tissue, and these enzymes are compatible with a continuous damage of the lung tissue by free radicals throughout the life span.
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