Changes in subcellular localisation of MI-ER1α, a novel oestrogen receptor-α interacting protein, is associated with breast cancer progression

@article{McCarthy2008ChangesIS,
  title={Changes in subcellular localisation of MI-ER1α, a novel oestrogen receptor-α interacting protein, is associated with breast cancer progression},
  author={Philip L McCarthy and F. Corinne Mercer and M W J Savicky and Beth A Carter and Gary D. Paterno and Laura L Gillespie},
  journal={British Journal of Cancer},
  year={2008},
  volume={99},
  pages={639 - 646}
}
The oestrogen receptor-α (ERα) plays a key role in breast development and tumorigenesis and inhibiting its activity remains a prime strategy in the treatment of ERα-positive breast cancers. Thus, elucidation of the molecular mechanisms responsible for regulating ERα activity may facilitate the design of new, more effective breast cancer therapies. The MI-ER1α is a novel transcriptional repressor that contains an LXXLL motif for interaction with nuclear hormone receptors. We investigated the… CONTINUE READING
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