Changes in spontaneous behavior in rats exposed to experimental disc herniation are blocked by selective TNF-alpha inhibition.

@article{Olmarker2003ChangesIS,
  title={Changes in spontaneous behavior in rats exposed to experimental disc herniation are blocked by selective TNF-alpha inhibition.},
  author={Kjell Olmarker and Magdalena Nutu and Rolf St\orkson},
  journal={Spine},
  year={2003},
  volume={28 15},
  pages={1635-41; discussion 1642}
}
STUDY DESIGN Study of pain behavior in animals by observation of changes in spontaneous behavior. OBJECTIVES To assess if selective inhibition of tumor necrosis factor alpha may reduce changes in spontaneous behavior induced by experimental disc herniation in the rat as previously reported. SUMMARY OF BACKGROUND DATA It is known that the proinflammatory cytokine tumor necrosis factor alpha may play a key role for the nucleus pulposus-induced nerve dysfunction seen in experimental set ups… CONTINUE READING