Changes in spermatozoal chromatin packaging and susceptibility to oxidative challenge during aging.

@article{Zubkova2005ChangesIS,
  title={Changes in spermatozoal chromatin packaging and susceptibility to oxidative challenge during aging.},
  author={Ekaterina V Zubkova and Michael Wade and Bernard Robaire},
  journal={Fertility and sterility},
  year={2005},
  volume={84 Suppl 2},
  pages={1191-8}
}
OBJECTIVE Our goal was to test the hypothesis that spermatozoal chromatin packaging changes with age and that aging affects the susceptibility of spermatozoal DNA to oxidative damage. DESIGN Laboratory study. SETTING Academic facility. PATIENT(S) Young (4 months) and old (21 months) Brown Norway rats. INTERVENTION(S) Spermatozoa were collected from the cauda epididymidis and were incubated in saline or H2O2. MAIN OUTCOME MEASUREMENT(S) Thiols levels, chromatin condensation, DNA… CONTINUE READING

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