Changes in specific cleavability of the Sendai virus fusion protein: implications for pathogenicity in mice.

@article{Tashiro1992ChangesIS,
  title={Changes in specific cleavability of the Sendai virus fusion protein: implications for pathogenicity in mice.},
  author={Masato Tashiro and Joseph Seto and S Choosakul and H. Hegemann and Hans Dieter Klenk and Rudolf Rott},
  journal={The Journal of general virology},
  year={1992},
  volume={73 ( Pt 6)},
  pages={1575-9}
}
Sendai virus mutants, KDe-21 and KDe-62, which had undergone multiple cycles of replication in Madin Darby canine kidney (MDCK) cells in the absence of exogenous proteases were isolated. The fusion (F) protein of the mutants regained proteolytic cleavability in MDCK cells and chick embryos, but the F protein remained non-cleavable in other cell lines. Unlike the F protein of wild-type (wt) virus, the mutant F was resistant to trypsin but was sensitive to elastase and, to a lesser extent, to… CONTINUE READING
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