Changes in somatic action potential shape in guinea-pig nociceptive primary afferent neurones during inflammation in vivo.


We have examined whether there are changes during inflammation in the membrane properties of nociceptive primary afferent neurones in the guinea-pig that might contribute to hyperalgesia. Inflammation was induced by intradermal injections of complete Freund's adjuvant (CFA) in the left leg. Intracellular voltage recordings were made from the somata of… (More)



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