Changes in sodium channel function during postnatal brain development reflect increases in the level of channel sialidation.

@article{Castillo1997ChangesIS,
  title={Changes in sodium channel function during postnatal brain development reflect increases in the level of channel sialidation.},
  author={Cecilia Castillo and Mar{\'i}a Eugenia Molina D{\'i}az and Domingo Balbi and William B. Thornhill and Esperanza Recio-Pinto},
  journal={Brain research. Developmental brain research},
  year={1997},
  volume={104 1-2},
  pages={119-30}
}
Developmental changes of forebrain sodium channels were studied at three postnatal ages: P0, P15 and adult (P30/P180). Electrophysiological analysis determined that the midpoint potential of activation was -64, -75 and -81 mV for P0, P15 and adult channels, respectively. At negative potentials, gating state changes were observed in all channels; at positive potentials they were observed in most P0 (72%) and to a lower extent in older channels (25%). A long non-conductive state was displayed… CONTINUE READING

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