Changes in skin levels of two neutotrophins (glial cell line derived neurotrophic factor and neurotrophin-3) cause alterations in cutaneous neuron responses to mechanical stimuli.

@article{Lawson2008ChangesIS,
  title={Changes in skin levels of two neutotrophins (glial cell line derived neurotrophic factor and neurotrophin-3) cause alterations in cutaneous neuron responses to mechanical stimuli.},
  author={Jeffrey J Lawson and Sabrina L. McIlwrath and H. Richard Koerber},
  journal={Sheng li xue bao : [Acta physiologica Sinica]},
  year={2008},
  volume={60 5},
  pages={584-96}
}
Neurotrophins are important for the development and maintenance of both high and low threshold mechanoreceptors (HTMRs and LTMRs). In this series of studies, the effects of constitutive overexpression of two different neurotrophins, neurotrophin-3 (NT-3) and glial cell line derived neurotrohic factor (GDNF), were examined. Previous studies indicated that both of them may be implicated in the normal development of mouse dorsal root ganglion (DRG) neurons. Neurons from mice transgenically altered… CONTINUE READING

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