Changes in size, subclass, and metabolic properties of serum immunoglobulin A in liver diseases and in other diseases with high serum immunoglobulin A.

@article{Delacroix1983ChangesIS,
  title={Changes in size, subclass, and metabolic properties of serum immunoglobulin A in liver diseases and in other diseases with high serum immunoglobulin A.},
  author={Dominique L. Delacroix and K B Elkom and Andr{\'e} Pierre Geubel and H J F Hodgson and C C Dive and Jean Pierrre Vaerman},
  journal={The Journal of clinical investigation},
  year={1983},
  volume={71 2},
  pages={358-67}
}
We have studied the relative contributions of monomeric (m-) and polymeric IgA (p-IgA) and of IgA1 and IgA2 to total serum IgA in healthy adults and patients with liver disease (LD) or with other diseases and high serum IgA. Serum concentration of total secretory component (SC) was also determined. In addition, fractional catabolic rates (FCR) and synthetic rates for both m- and p-IgA were measured in nine controls and nine cirrhotics. Our results support four main conclusions: (a) In healthy… CONTINUE READING

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