Changes in serum levels of kynurenine metabolites in paediatric patients affected by ADHD

@article{Evangelisti2017ChangesIS,
  title={Changes in serum levels of kynurenine metabolites in paediatric patients affected by ADHD},
  author={Melania Evangelisti and Pietro de Rossi and Jole Rabasco and Renato Donfrancesco and Luana Lionetto and Matilde Capi and Gabriele Sani and Maurizio Simmaco and Ferdinando Nicoletti and Maria Pia Villa},
  journal={European Child & Adolescent Psychiatry},
  year={2017},
  volume={26},
  pages={1433-1441}
}
This study aims at determining serum levels of tryptophan and other metabolites of the kynurenine pathway in children with attention deficit hyperactivity disorder (ADHD) compared to healthy controls. Such metabolites interact with glutamate receptors in the central nervous system, potentially modulating mechanisms that are pivotal in ADHD and thus potentially representing peripheral biomarkers of the disorder. We measured serum levels of tryptophan and some metabolites of the kynurenine… CONTINUE READING
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