Changes in serum insulin-like factor 3 during normal male puberty.

  title={Changes in serum insulin-like factor 3 during normal male puberty.},
  author={Alberto Ferlin and Andrea Garolla and Franco Rigon and Lucia Rasi Caldogno and Andrea Lenzi and C Foresta},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={91 9},
CONTEXT Insulin-like factor 3 (INSL3) is produced by the Leydig cells, and in adults, its secretion is dependent on the state of differentiation of these cells, which, in turn, is dependent on LH. However, the secretion and regulation of INSL3 during puberty is unknown. OBJECTIVE Our objective was to evaluate INSL3 concentrations during normal male puberty and the relation of INSL3 to LH, FSH, and testosterone. DESIGN AND SETTING We conducted a cross-sectional study from January to December… CONTINUE READING