Changes in serum free testosterone, sleep patterns, and 5-alpha-reductase type I activity influence changes in sebum excretion in female subjects.

@article{Bissonnette2015ChangesIS,
  title={Changes in serum free testosterone, sleep patterns, and 5-alpha-reductase type I activity influence changes in sebum excretion in female subjects.},
  author={R Bissonnette and Julian Risch and Kevin J McElwee and Philippe Marchessault and Chantal Bolduc and Simon Nigen and Catherine H Maari},
  journal={Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging},
  year={2015},
  volume={21 1},
  pages={47-53}
}
BACKGROUND/PURPOSE Sebum is thought to play an important role in acne vulgaris and sebum excretion rate (SER) is often used as a marker of efficacy in acne studies. This study explored factors that could induce intra-subject variability in SER. METHODS SER was measured twice, 7 days apart, on the forehead of 40 healthy subjects. At each visit, the following parameters were also evaluated: serum androgen levels, 5-alpha-reductase type I gene expression, forehead temperature, sleep habits, diet… CONTINUE READING